Primary Pulmonary Hypertension (PPH) Legal Assistance Lawyer
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WILLIS
LAW FIRM

5252 Westchester St.
Suite #275
Houston,Tx 77005

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Legal Assistance for PPH & Diet Drug Victims since 1997  

Prognosis of Primary Pulmonary Hypertension (PPH)

The clinical course of PPH is generally one of inexorable progression toward death. However, natural history studies vary in reporting and in case ascertainment, and utilize different definitions of survival duration (eg, the interval since onset of symptoms or the interval since diagnosis), so that a consensus about the rate of progression of the disease has been difficult to establish.

Among patients who do not undergo heart-lung transplantation, actuarial survival at 1 year is 68 to 77 percent; 2 years, 52 to 58 percent; 3 years, 40 to 56 percent; 4 years, 30 to 43 percent; and 5 years, 22 to 38 percent. The usual mechanisms of death are right ventricular failure (63 percent), pneumonia (7 percent), and sudden death (7 percent).

Primary Pulmonary Hypertension (PPH) Survival Rates

Despite the overall dismal prognosis, duration of survival ranges up to 10 years or more. Isolated instances of survival up to 24 years have been reported, as have rare cases of apparent regression of the disease.

A variety of indicators appear to have predictive value for short survival.

(1) Higher Pulmonary Vascular Resistance and Pressure: Most studies have found an inverse correlation between the pulmonary hemodynamic abnormality and survival. Among the 194 patients in the Patient Registry for the Characterization of Primary Pulmonary Hypertension, median survival for those with a mean pulmonary arterial pressure less than 55 mm Hg was 48 months, compared to 12 months for those with mean pulmonary arterial pressure of 85 mm Hg or more.

The implications may be that in these patients, the disease is more advanced or has progressed to a more severe level relatively rapidly (ie, by the time of correct diagnosis). The higher pressure imposes a greater workload on the right ventricle, contributing to death from right-sided heart failure, the most common cause of mortality.

Some studies, however, have failed to identify degree of pulmonary hypertension as a predictor of mortality, despite finding a correlation with pulmonary resistance.

(2) Absence of Favorable Response to Vasodilator Therapy: The response to vasodilator therapy has long been recognized as being predictive of survival. There are two potential components to this predictor. First, the ability of the pulmonary vasculature to respond to vasodilator agents may identify patients in a more vasoreactive (earlier) phase of the disease. Thus, those who demonstrate reduced pulmonary vascular resistance with acute administration of vasodilators tend to survive longer, and this may be independent of subsequent treatment status. Second, in addition to the predictive role of vasodilators, there is suggestive evidence that treatment with vasodilators may enhance survival. Preliminary data from a 12-week randomized survival study of PPH patients treated with prolonged intravenous prostacyclin also support this observation.

(3) Worse Functional Classification: Most patients with PPH are symptomatic at the time of diagnosis. Nevertheless, symptoms are presumably a late development in this disease, resulting mainly from end-organ (right ventricular) sequelae. Level of symptomatic deterioration may be considered a global clinical index of hemodynamic dysfunction. Among symptomatic patients, those exhibiting more symptomatic decompensation have shorter subsequent survival.In the registry, median survival for patients in New York Heart Association class I or II was 58.6 months; class III, 31.5 months; and in class IV, 6 months. (See PPH Classifications)

(4) Right Atrial Pressure (RAP) Elevation: Among measurable hemodynamic indices of right ventricular function, mean RAP elevation is highly predictive of survival. Mean RAP greater than 20 mm Hg corresponds to a median survival of 1 month, compared to 46 months survival for patients with mean RAP less than 10 mm Hg.

(5) Depressed Cardiac Output: Decreased cardiac output is associated with severity of PPH. It is caused by both high fixed resistance to blood flow through the pulmonary vasculature and right ventricular failure. Not unexpectedly, reduced cardiac output also correlates with reduced survival. Cardiac index less than 2.0 L/min/m2 is associated with a median survival of 17 months; cardiac index of 4.0 L/min/m2 or more increases median survival to 43 months.

(6) Low Pulmonary Arterial (Mixed Venous) Oxygen Desaturation: Low (less than 63 percent) 02 predicted a mean 3-year survival of 17 percent, whereas higher 02 predicted a mean survival of 55 percent at 3 years. The power of this factor is probably derived from its cumulative reflection of poor oxygenation due to reduced capacity, arterial hypoxemia, and low cardiac output.

LEGAL OPTIONS FOR PPH PATIENTS

treatment of  Primary Pulmonary Hypertension (PPH) symptoms, herbal fen phen pph,side effects, signs of pph, common symtoms of primary pulmonary hypertensionIf you or a loved one have been diagnosed with Primary Pulmonary Hypertension (PPH), then you may have a right to file a individual legal action against the manufacturers of the diet pills or others. Due to the nature of this serious and devastating disease process, PPH patients are urged to contact an attorney immediately after he or she has been informed of their Primary Pulmonary Hypertension diagnosis. Many important legal issues need to be addressed early after a PPH diagnosis, that can affect the outcome of the PPH litigation. Call us for a Free Confidential Consultation. Talk with a Board Certified Personal Injury Trial Lawyer about your legal rights of a PPH claim against the diet drug industry and others. No Fees or Expenses Charged unless we make a Recovery for You. 

Call Us Toll Free at 1-800-883-9858 or 1-800-468-4878 or E-mail us your questions on Free Case Evaluation Form.

 


PPH LAWYER

Primary Pulmonary Hypertension (PPH) Legal Assistance LawyerIf you or a loved one took diet drugs and recently have been given a diagnosis of Primary Pulmonary Hypertension (PPH), idiopathic pulmonary hypertension, pulmonary arterial hypertension, PAH or pulmonary hypertension, then call us for a Free PPH Lawsuit Consultation. Talk to a Personal Injury Trial Lawyer with over 20+ years of product liability trial experience that understands the complications of PPH, legal options for patients with PPH and diet drug related PPH lawsuits and litigation.

Since 1997, we have aggressively represented PPH patients in diet drug lawsuits against the makers of Fen -Phen, Redux and PPH lawsuits against the nutritional supplement industry on herbal ephedrine / ephedra / ma huang PPH lawsuits. Get PPH Lawsuit Help. Talk to a PPH Attorney now. Call Toll Free 1-800-883-9858 or E-mail us.

Primary Pulmonary Hypertension (PPH) Legal Assistance Lawyer

BOARD CERTIFIED

Primary Pulmonary Hypertension (PPH) Legal Assistance LawyerIf you have been diagnosed with PPH then it very important that you talk with an attorney. Mr. Willis is a Board Certified Personal Injury Trial Lawyer, certified by the Texas Board of Legal Specialization since 1988. No Fees or Court Costs or Expenses charged to the client unless we obtain a recovery for you. We never send you a bill for our services! Call us if you have a question.

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PPH INFO & FAQs

What are the most common PPH Symptoms? Primary Pulmonary Hypertension symptoms may include, Shortness of Breath, Constantly tired, no stamina, chest pains, ankle swelling, water retention, swelling in feet, fainting, bluish lips or skin tones and excessive fatigue after mild to moderate exertion.

How does the Fen Phen Settlement affect a PPH claim or is it too late to file a PPH Lawsuit ? Under the terms of the diet drug class action settlement can PPH victims can still file a separate lawsuit? Call us to discuss your particular facts of your PPH case.

What is PPH? PPH or primary pulmonary hypertension is condition is often fatal and is primarily found in female patients aged 20-40 years old. PPH a rare condition in which the blood pressure in the arteries of the lungs is abnormally high. The cause of PPH - primary pulmonary hypertension is believed to be linked to certain diet drugs, weight loss drugs Pondimin (fenfluramine), diet drug combination Fen-Phen, and Redux (Dexfenfluramine), ephedra, ma huang and other natural ephedrine alkaloids. It is considered a progressive lung disease, often leading to congestive heart failure, respiratory failure, and eventually death. Some PPH patients improve their life expectancy greatly with heart, lung and/or heart lung transplants.

What is the Life Expectancy of a PPH Patient? Sadly, once diagnosed with PPH, the average PPH survival rate is three years. Pregnant women with PPH, have higher rate of maternal mortality. PPH and pregnancy is a bad combination. Drug therapy is a treatment option for a woman with PPH while pregnant. PPH medical treatment options available to people with PPH include anticoagulants, Flolan, Tracleer, diuretics, vasodilators, calcium channel blocking drugs and supplemental oxygen.

The last time I ever took Fen Phen, Pondimin or Redux was back in 1997, but recently I have been diagnosed with PPH or Primary Pulmonary Hypertension. Is it too late to file a PPH claim or lawsuit? How long can I wait till I file a PPH lawsuit? Due to possible running of an applicable Statute of Limitations (filing deadlines for a PPH Lawsuit), it is VERY IMPORTANT that you discuss this with an PPH attorney experienced with clients with PPH and with a proven track record of hard work and dedication to his clients. In some states, the PPH victim may only have up to ONE YEAR to file a PPH lawsuit or litigation from the date of the diagnosis or injury. Filing deadlines for PPH claims in other states may be longer.

Primary Pulmonary Hypertension (PPH) Legal Assistance Lawyer

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