Primary Pulmonary Hypertension (PPH) Legal Assistance Lawyer
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WILLIS
LAW FIRM

5252 Westchester St.
Suite #275
Houston,Tx 77005

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1-800-883-9858
1-800-468-4878


Legal Assistance for PPH & Diet Drug Victims since 1997  

BOSENTAN - A Miracle Drug for Primary Pulmonary Hypertension (PPH) Patients

Bosentan Explained
 
Bosentan -Tracleer is the first oral endothelin receptor antagonist for pulmonary hypertension (PAH). Previous to its availability, patients would try oral vasodilators (such as calcium channel blockers) or intravenous Flolan  Bosentan tablets work by blocking the hormone endothelin that has been found to exist in a higher level with pulmonary hypertension and is harmful to the lung and pulmonary arteries. Bosentan works by lowering the levels of a naturally occurring vasoconstricter called endothelin in the blood. A lower endothelin level helps to reverse the effects of hypertension created because the damaged lung and pulmonary arteries have created a blood flow resistance.

Bosentan Warnings

The Bosentan product information has a black box warning about potential liver toxicity and potential to cause major birth defects. At least 3-fold elevations of liver enzymes (aminotransferases; ALT, AST) above the upper limit of normal are seen in about 11% of patients. These liver enzymes (i.e. liver function tests or LFTs) should be measured prior to initiation of treatment and then monthly.

Bosentan Adverse Reactions & Side Effects

Adverse reactions reported in clinical testing of Bosentan Tracleer include (but are not limited to) the following:

  • Headache
  • Nasopharyngitis (inflammation of the nose and pharynx)
  • Flushing
  • Edema, lower limb
  • Hypotension
  • Palpitations
  • Women who are pregnant, or who may become pregnant, should not take Bosentan Tracleer due to the risk of birth defects. Additionally, patients receiving Tracleer should undergo monthly liver monitoring to ensure that proper enzyme levels are maintained.

Bosentan has a FDA pregnancy category X rating. Tracleer Bosentan  is very likely to produce major birth defects if used by pregnancy women. Pregnancy must be excluded before the start of treatment and prevented thereafter by the use of a reliable method of contraception. Hormonal contraceptives, including oral, injectable and implantable contraceptives should not be used as the sole means of contraception because these may not be effective in patients receiving Tracleer. Co-administration of  Bosentan / Tracleer and cyclosporine is contraindicated because there may be markedly increased plasma concentrations of Tracleer. Co-administration of Tracleer and glyburide is contraindicated because of the increased risk of liver enzyme elevations.

How Bosenten Works

Endothelin-1 (ET-1) is a neurohormone, the effects of which are mediated by binding to ETA and ETB receptors in the endothelium and vascular smooth muscle. ET-1 concentrations are elevated in plasma and lung tissue of patients with pulmonary arterial hypertension, suggesting a pathogenic role for ET-1 in this disease. Bosentan is a specific and competitive antagonist at endothelin receptor types ETA and ETB . Bosentan has a slightly higher affinity for ETA receptors than for ETB receptors (from Tracleer Prescribing Information).

 
PPH- LAWSUITS - LEGAL OPTIONS FOR PPH VICTIMS

bosenten, Primary Pulmonary Hypertension (PPH) ,bosantan, bosanton, tracleer, bosenten pph drug therapy, flolan therapy, flolan pumpIf you or a loved one have been diagnosed with Primary Pulmonary Hypertension (PPH), then you may have a right to file a individual legal action against the manufacturers of the diet pills or other products that caused your PPH. Due to the nature of this serious and devastating disease process, PPH patients are urged to contact an attorney immediately after he or she has been informed of their Primary Pulmonary Hypertension diagnosis. Many important legal issues need to be addressed early after a PPH diagnosis, that can affect the outcome of the PPH litigation. Call us for a Free Confidential Consultation. Talk with a Board Certified Personal Injury Trial Lawyer about your legal rights of a PPH claim against the diet drug industry and others. No Fees or Expenses Charged unless we make a Recovery for You. 

Call Us Toll Free at 1-800-883-9858 or 1-800-468-4878 or E-mail us your questions on Free Case Evaluation Form.

 
 
also see discussions of other PPH Drugs below:
 
 
 
 

 


PPH LAWYER

Primary Pulmonary Hypertension (PPH) Legal Assistance LawyerIf you or a loved one took diet drugs and recently have been given a diagnosis of Primary Pulmonary Hypertension (PPH), idiopathic pulmonary hypertension, pulmonary arterial hypertension, PAH or pulmonary hypertension, then call us for a Free PPH Lawsuit Consultation. Talk to a Personal Injury Trial Lawyer with over 20+ years of product liability trial experience that understands the complications of PPH, legal options for patients with PPH and diet drug related PPH lawsuits and litigation.

Since 1997, we have aggressively represented PPH patients in diet drug lawsuits against the makers of Fen -Phen, Redux and PPH lawsuits against the nutritional supplement industry on herbal ephedrine / ephedra / ma huang PPH lawsuits. Get PPH Lawsuit Help. Talk to a PPH Attorney now. Call Toll Free 1-800-883-9858 or E-mail us.

Primary Pulmonary Hypertension (PPH) Legal Assistance Lawyer

BOARD CERTIFIED

Primary Pulmonary Hypertension (PPH) Legal Assistance LawyerIf you have been diagnosed with PPH then it very important that you talk with an attorney. Mr. Willis is a Board Certified Personal Injury Trial Lawyer, certified by the Texas Board of Legal Specialization since 1988. No Fees or Court Costs or Expenses charged to the client unless we obtain a recovery for you. We never send you a bill for our services! Call us if you have a question.

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Primary Pulmonary Hypertension (PPH) Legal Assistance Lawyer

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