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WILLIS
LAW FIRM

5252 Westchester St.
Suite #275
Houston,Tx 77005

TOLL FREE
1-800-883-9858
1-800-468-4878


Legal Assistance for PPH & Diet Drug Victims since 1997  

PROSTACYCLIN

New Wonder Drug for Treatment of Primary Pulmonaty Hypertension (PPH) 

Prostacyclin (PGI2) also known as Epoprostenol, is a powerful strong vasodilator and an inhibitor of platelet aggregation.Prostacyclin is licensed as an anticoagulant for use during renal dialysis, but was granted approval for use for severe PPH by the Federal Drug Administration in 1996. Prostacyclin therapy was initially used as a bridge to lung transplantation although it has also emerged as an alternative to transplantation in some patients. It is now advocated as a treatment of severe PPH. Since first described in 1984, a number of studies have found evidence of significant morbidity and mortality benefits to patients with severe primary pulmonary hypertension from prostacyclin treatment. In addition, the improvements in life expectancy increase the chances of a patient receiving a heart and lung transplant. Prostacyclin may also be associated with better outcomes for heart-lung transplantations. Observations on prostacyclin can be generalized to newer analogues such as iloprost. Although doctors are not certain exactly how Prostacyclin works. It does have several measurable effects.

How Prostacylin Works ?

Prostacyclin dilates blood vessels to some extent and it reduces blood clotting by stopping platelets (in the blood) from sticking together. Researchers believe that an abnormally low ratio of prostacyclin in relation to endogenous thromboxane (a vasoconstrictor that serves the opposite function: it stimulates platelet aggregation) may be partially responsible for the development of primary pulmonary hypertension. Thus prostacyclin improves cardiac output- the blood vessels are cleared out and it may slow the growth of muscle cells that cause these blood vessels to constrict. A downside to prostacyclin treatment is that it expires quickly and must be infused continuously by an automated syringe pump and through a permanent catheter. Also, the delivery system is complex and requires patients to learn the techniques of sterile preparation, operation of the pump, and care of the intravenous catheter. In some cases this type of infusion may create serious complications (e.g., sepsis, thromboembolism, or syncope) related to the use of an implanted central vein catheter. While the original delivery system for prostacyclin was intravenoous, there are new prostacyclin therapy options which include injection, oral / inhaled spray mist of prostacyclin and oral tablets of prostacyclin.

Prostacyclin is also known as Flolan, Remodulin (UT-15 or Uniprost), Iloprost and Beraprost

             Flolan -a synthetic administered intravenously directly into the bloodstream through a surgically implanted catheter

             Remodulin (UT-15 / Uniprost) - prostacyclin injected subcutaneously (under the skin) with a needle

             Iloprost - inhaled form of Prostacyclin

             Beraprost - the oral form of Prostacyclin made by United Therapeutics

Other New PPH Drugs Include:

            Bosentan (Tracleer) - orally active endothelin receptor antagonist by Actelion

 


PPH LAWYER

Primary Pulmonary Hypertension (PPH) Legal Assistance LawyerIf you or a loved one took diet drugs and recently have been given a diagnosis of Primary Pulmonary Hypertension (PPH), idiopathic pulmonary hypertension, pulmonary arterial hypertension, PAH or pulmonary hypertension, then call us for a Free PPH Lawsuit Consultation. Talk to a Personal Injury Trial Lawyer with over 20+ years of product liability trial experience that understands the complications of PPH, legal options for patients with PPH and diet drug related PPH lawsuits and litigation.

Since 1997, we have aggressively represented PPH patients in diet drug lawsuits against the makers of Fen -Phen, Redux and PPH lawsuits against the nutritional supplement industry on herbal ephedrine / ephedra / ma huang PPH lawsuits. Get PPH Lawsuit Help. Talk to a PPH Attorney now. Call Toll Free 1-800-883-9858 or E-mail us.

Primary Pulmonary Hypertension (PPH) Legal Assistance Lawyer

BOARD CERTIFIED

Primary Pulmonary Hypertension (PPH) Legal Assistance LawyerIf you have been diagnosed with PPH then it very important that you talk with an attorney. Mr. Willis is a Board Certified Personal Injury Trial Lawyer, certified by the Texas Board of Legal Specialization since 1988. No Fees or Court Costs or Expenses charged to the client unless we obtain a recovery for you. We never send you a bill for our services! Call us if you have a question.

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