Primary Pulmonary Hypertension (PPH) Legal Assistance Lawyer
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WILLIS
LAW FIRM

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Suite #275
Houston,Tx 77005

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Legal Assistance for PPH & Diet Drug Victims since 1997  

REMODULIN (UT-15) - NEW PROSTACYCLIN DRUG TO TREAT PPH

Remodulin (treprostinil sodium) injection is a continuous subcutaneous infusion for the treatment of pulmonary arterial hypertension (PAH) in patients with NYHA Class II-IV symptoms. Remodulin is intended to diminish the symptoms, such as shortness of breath, associated with physical activity in PAH patients. Remodulin is supplied in concentrations of 1.0 mg/mL, 2.5 mg/mL, 5.0 mg/mL and 10.0 mg/mL. The standard infusion rate is 1.25 ng/kg/min, but can be reduced in the event that the original dose cannot be tolerated.

Remodulin is also used to treat pulmonary hypertension in the form of a synthetic, stable form of prostacyclin. This pulmonary hypertension treatment is a new treatment approved under accelerated approval regulations for advanced pulmonary hypertension. Manufactured by United Therapeutics, Remodulin was FDA approved on May 22, 2002 based on the largest double blind placebo-controlled study ever conducted in PAH. Pulmonary arterial hypertension (PAH) is a disease in which blood pressure is abnormally high in the arteries between the heart and lungs. PAH is characterized by symptoms of shortness of breath during physical exertion. The condition can ultimately lead to heart failure.

The approval of Remodulin was encouraging news for many patients and doctors due to the need for expanded treatment options for pulmonary hypertension patients. Remodulin was made immediately available through United Therapeutics U.S. distributors. The benefit of using Remodulin over already available Flolan is the longevity it remains within the body.

Flolan - Remodulin PPH Therapy

Opposed to Flolan therapy, Remodulin's dilation action lasts from 4-6 hours versus the 2-3 minute action of Flolan. In addition, Remodulin is administered under the skin called subcutaneous infusion, working with a MiniMed microinfusion device. The use of Remodulin carries a much lower risk of sepsis and other related hospitalizations that is associated to the use of Flolan because the elimination of the need for a catheter.

Two 12-week, multicenter, randomized, double-blind studies were conducted to compare Remodulin to placebo. A total of 470 subjects with NYHA Class II-IV pulmonary arterial hypertension (PAH) we enrolled in the studies. The baseline measures were 6-minute walking distance and level of shortness of breath during this physical test (Borg dyspnea score). The primary endpoint was change in 6-minute walking distance over the 12-week treatment period. There was a noteworthy change in 6-minute walking distance for those subjects treated with Remodulin, although the effects did not achieve conventional levels of statistical significance. There was a statistically significant change in subjects' Borg dyspnea scores with the Remodulin treatment. There were significant differences between Remodulin- and placebo-treated subjects in eight out of ten hemodynamic parameters that were evaluated, including cardiac index; mean pulmonary arterial pressure; pulmonary vascular resistance indexed; mean right atrial pressure; systemic vascular resistance indexed; mixed venous oxygen saturation. The two hemodynamic parameters that did not achieve statistical significance were mean systemic arterial pressure and heart rate.

At the time of FDA approval, clinical studies of Remodulin were still ongoing for the PAH indication to explore further effects and potential benefits of the drug. In addition, a post-marketing, phase IV clinical trial is expected to commence.

Remodulin Side Effects may include:

  • Hypotension
  • Edema
  • infusion site pain
  • infusion site reaction
  • headache
  • diarrhe
  • nausea
  • rash
  • jaw pain
  • vasodilatation
  • dizziness
  • edema
  • pruritus (itching)

PPH LAWSUITS - LEGAL & FINANCIAL HELP FOR PPH VICTIMS

flolan remodulin  treatment, remodulin  therapy ,  remodulin side effects, Primary Pulmonary Hypertension (PPH) , remodulin drug therapy, flolan pump If you or a loved one have been diagnosed with Primary Pulmonary Hypertension (PPH), then you may have a right to file a individual legal action against the manufacturers of the diet pills or other products that caused your PPH. Due to the nature of this serious and devastating disease process, PPH patients are urged to contact an attorney immediately after he or she has been informed of their Primary Pulmonary Hypertension diagnosis. Many important legal issues need to be addressed early after a PPH diagnosis, that can affect the outcome of the PPH litigation. Call us for a Free Confidential Consultation. Talk with a Board Certified Personal Injury Trial Lawyer about your legal rights of a PPH claim against the diet drug industry and others. No Fees or Expenses Charged unless we make a Recovery for You. 

Call Us Toll Free at 1-800-883-9858 or 1-800-468-4878 or E-mail us your questions on Free Case Evaluation Form.

 


PPH LAWYER

Primary Pulmonary Hypertension (PPH) Legal Assistance LawyerIf you or a loved one took diet drugs and recently have been given a diagnosis of Primary Pulmonary Hypertension (PPH), idiopathic pulmonary hypertension, pulmonary arterial hypertension, PAH or pulmonary hypertension, then call us for a Free PPH Lawsuit Consultation. Talk to a Personal Injury Trial Lawyer with over 20+ years of product liability trial experience that understands the complications of PPH, legal options for patients with PPH and diet drug related PPH lawsuits and litigation.

Since 1997, we have aggressively represented PPH patients in diet drug lawsuits against the makers of Fen -Phen, Redux and PPH lawsuits against the nutritional supplement industry on herbal ephedrine / ephedra / ma huang PPH lawsuits. Get PPH Lawsuit Help. Talk to a PPH Attorney now. Call Toll Free 1-800-883-9858 or E-mail us.

Primary Pulmonary Hypertension (PPH) Legal Assistance Lawyer

BOARD CERTIFIED

Primary Pulmonary Hypertension (PPH) Legal Assistance LawyerIf you have been diagnosed with PPH then it very important that you talk with an attorney. Mr. Willis is a Board Certified Personal Injury Trial Lawyer, certified by the Texas Board of Legal Specialization since 1988. No Fees or Court Costs or Expenses charged to the client unless we obtain a recovery for you. We never send you a bill for our services! Call us if you have a question.

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Primary Pulmonary Hypertension (PPH) Legal Assistance Lawyer

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